Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Wnk3 |
| Gene Name: | WNK3 |
| Protein Full Name: | Serine/threonine-protein kinase WNK3 |
| Alias: | EC 2.7.11.1; KIAA1566; PRKWNK3; Protein kinase, lysine-deficient 3 |
| Mass (Da): | 191789 |
| Number AA: | 1743 |
| UniProt ID: | Q9BYP7 |
| Locus ID: | 65267 |
| COSMIC ID: | WNK3 |
| Gene location on chromosome: | Xp11.22 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20000 |
| Percent of cancer specimens with mutations: | 1.43 |
| Normal role description: | WNK3 is a serine-threonine protein kinase that lack the catalytic lysine in subdomain II, and instead has a conserved lysine in subdomain I. It functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. |
| Commentary on involvement of protein in cancer: | 1/53 CNS-, and 2/114 kidney tumour samples were also mutated |