Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RHOBTB2 |
| Gene Name: | RHOBTB2 |
| Protein Full Name: | Rho-related BTB domain-containing protein 2 |
| Alias: | Deleted in breast cancer 2 gene protein;p83 |
| Mass (Da): | 82626 |
| Number AA: | 727 |
| UniProt ID: | Q9BYZ6 |
| Locus ID: | 23221 |
| COSMIC ID: | RHOBTB2 |
| Gene location on chromosome: | 8p21.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19995 |
| Percent of cancer specimens with mutations: | 0.61 |
| Gene undergoes hypermethylation: | Bladder cancer |
| Normal role description: | RHOBTB2 is a monomeric GTPase from the Rho family that functions as an adapter protein for cullin-3, a ubiquitin E3 ligase necessary for mitotic cell division. Homozygous deletions of the gene have been seen in breast cancer tumours, and it is thus considered a candidate tumour suppressor. It has also been found to inhibit the growth and metastasis of certain subsets of breast cancer. |
| Commentary on involvement of protein in cancer: | Only 2 ovarian cancer samples were included in Sanger COSMIC. 1/200 lung cancer samples were also mutated. |