Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | WHSC1L1 |
| Gene Name: | WHSC1L1 |
| Protein Full Name: | Histone-lysine N-methyltransferase NSD3 |
| Alias: | FLJ20353; NSD3; Nuclear SET domain-containing protein 3; Whistle; WHSC1-like 1; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine; Wolf-Hirschhorn syndrome candidate 1-like 1; Wolf-Hirschhorn syndrome candidate 1-like 1 (NSD3); Wolf-Hirschhorn syndrome candidate 1-like protein 1 |
| Mass (Da): | 161594 |
| Number AA: | 1437 |
| UniProt ID: | Q9BZ95 |
| Locus ID: | 54904 |
| COSMIC ID: | WHSC1L1 |
| Gene location on chromosome: | 8p11.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20357 |
| Percent of cancer specimens with mutations: | 0.34 |
| Deregulated in translocations: | NUP98 |
| Normal role description: | WHSC1L1 is involved in histone methylation and regulates transcription repression. Translocation event is associated with acute non lymphocytic leukemia. |