Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FOXP3 |
| Gene Name: | FOXP3 |
| Protein Full Name: | Forkhead box protein P3 |
| Alias: | Scurfin |
| Mass (Da): | 47244 |
| Number AA: | 431 |
| UniProt ID: | Q9BZS1 |
| Locus ID: | 50943 |
| COSMIC ID: | FOXP3 |
| Gene location on chromosome: | Xp11.23 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.29 |
| Normal role description: | FOXP3 is a X-linked transcriptional regulator of the forkhead/winged-helix family. It is crucial in regulation of function and development of regulatory T cells. Interacts with and inhibits transcription activity of ERBB2 and SKP2, which leads to inhibition of cell growth in breast cancer cells. Deletion and LOH common in breast tumors, 80% were shown to have decreased FOXP3 expression. |