Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SENP6 |
| Gene Name: | SENP6 |
| Protein Full Name: | Sentrin-specific protease 6 |
| Alias: | FKSG6; KIAA0797; Protease FKSG6; SEN6; Sentrin/sumo-specific protease SENP6; SSP1; Sumo-1 specific protease 1; SUMO1/sentrin specific peptidase 6; SUSP1 |
| Mass (Da): | 126146 |
| Number AA: | 1112 |
| UniProt ID: | Q9GZR1 |
| Locus ID: | 26054 |
| COSMIC ID: | SENP6 |
| Gene location on chromosome: | 6q14.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20235 |
| Percent of cancer specimens with mutations: | 0.69 |
| Deregulated in translocations: | SENP6-TCBA1 fusion in HT-1 T-cell lymphoma/leukemia cell line |
| Normal role description: | SENP6 is a protease that deconjugates SUMO1/2/3 from targeted proteins. It is involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. It also desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation; and also RPA1, thereby preventing RAD51-recruitment to the DNA damage foci to initiate DNA repair through homologous recombination. |
| Commentary on involvement of protein in cancer: | Only 2 bladder cancer samples were included in Sanger COSMIC; 2/186 breast-, 1/145 lung-, and 1/59 ovarian samples were also mutated |