Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | WWTR1 |
| Gene Name: | WWTR1 |
| Protein Full Name: | WW domain-containing transcription regulator prote |
| Alias: | DKFZp586I1419; TAZ; Transcriptional coactivator with PDZ-binding motif; WW domain containing transcription regulator 1; WW domain containing transcription regulator protein 1 |
| Mass (Da): | 44101 |
| Number AA: | 400 |
| UniProt ID: | Q9GZV5 |
| Locus ID: | 25937 |
| COSMIC ID: | WWTR1 |
| Gene location on chromosome: | 3q23-q2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.39 |
| Normal role description: | WWTR1 is a transcription factor that postively reguates the Hippo signalling pathway. The Hippo pathway plays a critical role in regulating organ size and tumour suppression by inhibiting cell growth and promoting apoptosis. Mutations in this gene have been observed in breast tumors. |