Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | WWP1 |
| Gene Name: | WWP1 |
| Protein Full Name: | NEDD4-like E3 ubiquitin-protein ligase WWP1 |
| Alias: | AIP5; atropin-1-interacting protein 5; DKFZP434D2111; WW domain containing E3 ubiquitin protein ligase 1; WW domain-containing protein 1 |
| Mass (Da): | 105202 |
| Number AA: | 922 |
| UniProt ID: | Q9H0M0 |
| Locus ID: | 11059 |
| COSMIC ID: | WWP1 |
| Gene location on chromosome: | 8q21 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20240 |
| Percent of cancer specimens with mutations: | 0.8 |
| Found in amplified chromosomal regions in human cancers: | prostate cancer cell lines/xenografts/tumours (31-44%); breast cancer cell lines/tumors (41-51%) |
| Normal role description: | E3 ubiquitin-protein ligase that negatively regulates TGF-beta signalling by ubiquitination of TGFbeta receptor 1 and other proteins for subsequent degradation. Inhibits p53 activity through exporting p53 from the nucleus after ubiquitination. Suggested to play a pro-survival role in several human cancers, such as breast and prostate cancer. |