Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TRPV6 |
| Gene Name: | TRPV6 |
| Protein Full Name: | Transient receptor potential cation channel subfam |
| Alias: | Calcium transport protein 1; CaT1; CaT-L; CaT-like; ECaC2; Epithelial calcium channel 2; TrpV6 |
| Mass (Da): | 83210 |
| Number AA: | 725 |
| UniProt ID: | Q9H1D0 |
| Locus ID: | 55503 |
| COSMIC ID: | TRPV6 |
| Gene location on chromosome: | 7q34 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 1.09 |
| Normal role description: | PRPV6 is an pical Ca2+ entry pathway for total body calcium homeostasis in the small intestine under the control of 1,25-dihydroxyvitamin D3.TRPV6 is involved in an increase in proliferation and apoptotic resistance in cancer cells through an unknown mechanism. It is significantly upregulated in locally advanced prostate cancer and also breast cancers |