Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SLC38A1 |
| Gene Name: | SLC38A1 |
| Protein Full Name: | Sodium-coupled neutral amino acid transporter 1 |
| Alias: | Amino acid transporter A1; N-system amino acid transporter 2; S38A1; Sodium-coupled neutral amino acid transporter 1: Amino acid transporter A1: System A amino acid transporter 1: System N amino acid transporter 1: N-system amino acid transporter 2: Solute carrier family 38 member 1; Solute carrier family 38 member 1; System A amino acid transporter 1; System N amino acid transporter 1 |
| Mass (Da): | 54048 |
| Number AA: | 487 |
| UniProt ID: | Q9H2H9 |
| Locus ID: | 81539 |
| COSMIC ID: | SLC38A1 |
| Gene location on chromosome: | 12q13.11 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.6 |
| Normal role description: | Transporter - for amino acids. Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA. Down-regulated by bacterial lipopolysaccharides (LPS) in glial cells. Down-regulated upon hypoxia. In cancer it is upregulated and promotes growth and survival. |