Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TAOK3 |
| Gene Name: | TAOK3 |
| Protein Full Name: | Serine/threonine-protein kinase TAO3 |
| Alias: | DPK; EC 2.7.11.1; JIK; Kinase TAO3; MAP3K18; TAO kinase 3 |
| Mass (Da): | 105406 |
| Number AA: | 898 |
| UniProt ID: | Q9H2K8 |
| Locus ID: | 51347 |
| COSMIC ID: | TAOK3 |
| Gene location on chromosome: | 12q |
| Number of cancer specimens: | 20002 |
| Percent of cancer specimens with mutations: | 0.59 |
| Commentary on involvement of protein in cancer: | Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). |