Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FOXP1 |
| Gene Name: | FOXP1 |
| Protein Full Name: | Forkhead box protein P1 |
| Alias: | 12CC4; Fork head-related protein like B; Forkhead box P1; Glutamine-rich factor 1; HSPC215; PAX5/FOXP1 fusion protein; QRF1 |
| Mass (Da): | 75320 |
| Number AA: | 677 |
| UniProt ID: | Q9H334 |
| Locus ID: | 27086 |
| COSMIC ID: | FOXP1 |
| Gene location on chromosome: | 3p14.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20113 |
| Percent of cancer specimens with mutations: | 0.79 |
| Deregulated in translocations: | B-progenitor Acute Lymphoid Leukemia. Fusion partners include PAX5; Marginal Zone B-cell lymphoma and diffuse large B cell lymphoma. Fusion partners include IGH, MALT1 and BCL-10 |
| Normal role description: | Acts as a transcription repressor and regulate tissue and cell type specific gene transcription during both development and adult hood. |