Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | WNK1 |
| Gene Name: | WNK1 |
| Protein Full Name: | Serine/threonine-protein kinase WNK1 |
| Alias: | EC 2.7.11.1; PRKWNK1; Protein kinase with no lysine 1; Protein kinase, lysine-deficient 1 |
| Mass (Da): | 250756 |
| Number AA: | 2382 |
| UniProt ID: | Q9H4A3 |
| Locus ID: | 65125 |
| COSMIC ID: | WNK1 |
| Gene location on chromosome: | 12p13.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20405 |
| Percent of cancer specimens with mutations: | 1.63 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with point mutations across entire protein, but no complex mutations, insertions or deletions. |
| Normal role description: | Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signalling, survival, and proliferation.WNK1 activates SCNN1A, SCNN1B, SCNN1D and SGK1. Exact mechanism of oncogenesis is unclear. |