Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PLK3 |
| Gene Name: | PLK3 |
| Protein Full Name: | Serine/threonine-protein kinase PLK3 |
| Alias: | CNK; Cytokine-inducible serine/threonine-protein kinase; EC 2.7.11.21; FGF-inducible kinase; FNK; Kinase PLK3; PLK-3; Polo-like kinase 3; PRK; Proliferation-related kinase |
| Mass (Da): | 71629 |
| Number AA: | 646 |
| UniProt ID: | Q9H4B4 |
| Locus ID: | 1263 |
| COSMIC ID: | PLK3 |
| Gene location on chromosome: | 1p34.1 |
| Number of cancer specimens: | 19828 |
| Percent of cancer specimens with mutations: | 0.46 |
| Normal role description: | PLK3 is a protein-serine/threonine kinase. |
| Commentary on involvement of protein in cancer: | Serine/threonine protein kinase involved in regulating M phase functions during the cell cycle. May also be part of the signaling network controlling cellular adhesion. In vitro, is able to phosphorylate CDC25C and casein. |