Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | BCAS3 |
| Gene Name: | BCAS3 |
| Protein Full Name: | Breast carcinoma-amplified sequence 3 |
| Alias: | Breast carcinoma amplified sequence 3; FLJ20128; GAOB1; Maab1 protein |
| Mass (Da): | 101181 |
| Number AA: | 928 |
| UniProt ID: | Q9H6U6 |
| Locus ID: | 54828 |
| COSMIC ID: | BCAS3 |
| Gene location on chromosome: | 17q23 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19688 |
| Percent of cancer specimens with mutations: | 0.85 |
| Deregulated in translocations: | Breast Cancer. Fusion partner BCAS4. |
| Normal role description: | BCA3 Is a ubiquitously expressed protein of which very little functional data is available. This protein has been found to be overexpressed in 10% of breast cancer cell lines. Translocation events involving fusion of BCAS3 to BCAS4 were found in a breast cancer cell line. |