Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SMYD3 |
| Gene Name: | SMYD3 |
| Protein Full Name: | SET and MYND domain-containing protein 3 |
| Alias: | ZMYND1, ZNFN3A1 |
| Mass (Da): | 49083 |
| Number AA: | 428 |
| UniProt ID: | Q9H7B4 |
| Locus ID: | 64754 |
| COSMIC ID: | SMYD3 |
| Gene location on chromosome: | 1q44 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.4 |
| Normal role description: | SMYD3 is a histone methyltransferase that functions in RNA polymerase II complexes via interaction with a certain RNA helicase, HELZ. It is thought to be an important factor in oncogenesis. Upregulation of this gene is associated with various cancers, including: colon, liver, breast, cervical, myelomas, and head and neck tumors. |