Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SCAF1 |
| Gene Name: | SCAF1 |
| Protein Full Name: | Splicing factor, arginine/serine-rich 19 |
| Alias: | FLJ00034; SCAF; Serine arginine-rich pre-mRNA splicing factor SR-A1; SFR19; Splicing factor, arginine/serine-rich 19; Splicing factor, arginine/serine-rich 19: Serine arginine-rich pre-mRNA splicing factor SR-A1: SR-related-CTD-associated factor; SR-A1; SR-related CTD-associated factor 1; SR-related-CTD-associated factor |
| Mass (Da): | 139266 |
| Number AA: | 1312 |
| UniProt ID: | Q9H7N4 |
| Locus ID: | 58506 |
| COSMIC ID: | SCAF1 |
| Gene location on chromosome: | 19q13.33 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19603 |
| Percent of cancer specimens with mutations: | 0.97 |
| Normal role description: | Interact with RNA Polymerase II. May be involved in pre-mRNA splicing. Expression associated with poor prognosis and tumour progression in breast, ovarian and colon cancer. |
| Commentary on involvement of protein in cancer: | The Atlas of Oncology does not report any mutations. |