Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PLEKHG2 |
| Gene Name: | PLEKHG2 |
| Protein Full Name: | Pleckstrin homology domain-containing family G mem |
| Alias: | CLG; PKHG2; Pleckstrin homology domain-containing family G member 2: Pleckstrin homology domain-containing family G member 2 |
| Mass (Da): | 147915 |
| Number AA: | 1386 |
| UniProt ID: | Q9H7P9 |
| Locus ID: | 64857 |
| COSMIC ID: | PLEKHG2 |
| Gene location on chromosome: | 19q13.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19763 |
| Percent of cancer specimens with mutations: | 1.09 |
| Normal role description: | PLEKHG2 is a guanine-nucleotide exchange factor for RAC1 and CDC42 that is activated by binding to the βγ subunits heterotrimeric G proteins via its N-terminal. It may also be a functioning as a transforming oncogene. |
| Commentary on involvement of protein in cancer: | 1 pharyngeal sample was also mutated (silent) |