Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ZNF442 |
| Gene Name: | ZNF442 |
| Protein Full Name: | Zinc finger protein 442 |
| Mass (Da): | 72863 |
| Number AA: | 627 |
| UniProt ID: | Q9H7R0 |
| Locus ID: | 7705 |
| COSMIC ID: | ZNF442 |
| Gene location on chromosome: | 19p13.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20121 |
| Percent of cancer specimens with mutations: | 0.68 |
| Normal role description: | ZNF442 is a poorly characterized zinc-finger domain containing protein which may bind DNA. Somatic mis-sense mutations have been detected in colorectal and renal cell carcinomas, however their functional effect has not been characterized. |
| Commentary on involvement of protein in cancer: | Less than 3% mutations in breast. |