Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ZNF703 |
| Gene Name: | ZNF703 |
| Protein Full Name: | Zinc finger protein 703 |
| Alias: | FLJ14299; Zn703; Znf503l; Znf703 |
| Mass (Da): | 58222 |
| Number AA: | 590 |
| UniProt ID: | Q9H7S9 |
| Locus ID: | 80139 |
| COSMIC ID: | ZNF703 |
| Gene location on chromosome: | 8p11.23 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20057 |
| Percent of cancer specimens with mutations: | 0.2 |
| Found in amplified chromosomal regions in human cancers: | Luminal B breast cancers (33%) |
| Normal role description: | ZNF703 is a transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. ZNF703 regulates cell adhesion, migration and proliferation. Amplification of a distal 8p12 locus occurs in around one third of the luminal B breast cancers and ZNF703 is the single gene within the minimal amplicon. Amplification of the gene correlates with its increased protein expression in tumour cells. ZNF703 is a classical breast cancer oncogene since it is able to transform non-malignant cells and increase cellular proliferation. |
| Commentary on involvement of protein in cancer: | Only 2 substitution mutations identified, one each in breast and panceatic cancers. |