Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ECT2 |
| Gene Name: | ECT2 |
| Protein Full Name: | Protein ECT2 |
| Alias: | Epithelial cell transforming sequence 2 oncogene; Epithelial cell-transforming sequence 2 oncogene |
| Mass (Da): | 100051 |
| Number AA: | 883 |
| UniProt ID: | Q9H8V3 |
| Locus ID: | 1894 |
| COSMIC ID: | ECT2 |
| Gene location on chromosome: | 3q26.31 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20214 |
| Percent of cancer specimens with mutations: | 0.7 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | ECT2 is a G protein binding protein that may function as a guanine nucleotide exchange factor. It may promote nucleotide exchange on Rho family members such as RhoA, RhoC, Rac1 and Cdc42. It stimulates Rac1 through its association with the PARD6A-PRKCI complex in cancer cells and drive tumour proliferation and invasion. However, it was also found to stimulate stress-induced RhoB activity in breast cancer cells and triggering apoptosis. It is required for the regulation of cytokinesis including mitotic spindle assembly. In the nervous system, it may also play a role in the regulation of neurite outgrowth. |