Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | BCL2L12 |
| Gene Name: | BCL2L12 |
| Protein Full Name: | Bcl-2-like protein 12 |
| Alias: | B2L12; BCL2-like 12; BCL2-like 12 (proline rich) |
| Mass (Da): | 36821 |
| Number AA: | 334 |
| UniProt ID: | Q9HB09 |
| Locus ID: | 83596 |
| COSMIC ID: | BCL2L12 |
| Gene location on chromosome: | 19q13.3 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.33 |
| Normal role description: | The exact function of BCL2L12 is unknown, but we do know that is involved in apoptosis. However, its pro-apoptotic or anti-apoptotic role in different types of cells and conditions remains unclear. It appears to be functioning as an oncoprotein in some tissues and as a tumour suppressor in others. No mutations of the gene have been identified as being cancer-related. |