Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SP110 |
| Gene Name: | SP110 |
| Protein Full Name: | Sp110 nuclear body protein |
| Alias: | Transcriptional coactivator Sp110 |
| Mass (Da): | 78477 |
| Number AA: | 689 |
| UniProt ID: | Q9HB58 ; B4DVI4 |
| Locus ID: | 3431 |
| COSMIC ID: | SP110 |
| Gene location on chromosome: | 2q37.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19688 |
| Percent of cancer specimens with mutations: | 0.61 |
| Normal role description: | SP110 is a transcription factor which may function as a coactivator for nuclear hormone receptors. This protein is expressed primarily in peripheral blood leukocytes and has a role in mediating immune responses to bacterial infection caused by tuberculosis. Primarily mis-sense mutations have been identified in breast cancer samples. These mutations however are not well characterized functionally. Due to SP110's role in regulating transcription, dysfunction may lead to aberrant expression of genes associated with cancer development. |
| Commentary on involvement of protein in cancer: | No entry in Atlasgeneticsoncology.org |