Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PARVB |
| Gene Name: | PARVB |
| Protein Full Name: | Beta-parvin |
| Alias: | Affixin; CGI-56; PARB; Parvin beta; Parvin, beta |
| Mass (Da): | 41714 |
| Number AA: | 364 |
| UniProt ID: | Q9HBI1 |
| Locus ID: | 29780 |
| COSMIC ID: | PARVB |
| Gene location on chromosome: | 22q13.31 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.37 |
| Normal role description: | PARVB is an actin binding protein that regulates cytoskeleton organization and cell adhesion. It can regulate integrin-linked kinase inhibition activity, reduce AKT phosphorylation through protein interaction, regulate Rac1 signalling, and activate PPARg transcription. Reduced expression or deletion of gene is often seen in breast cancer and is associated with ILK overexpression resulting in dysregulation of cell adhesion and promotion of cell migration. |