Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | EML4 |
| Gene Name: | EML4 |
| Protein Full Name: | Echinoderm microtubule-associated protein-like 4 |
| Alias: | C2ORF2; Echinoderm microtubule associated protein like 4; Echinoderm microtubule-associated protein-like 4; ELP120; EMAL4; EMAP-4; EMAPL4; Restrictedly overexpressed proliferation-associated protein; Ropp 120; ROPP120 |
| Mass (Da): | 108903 |
| Number AA: | 981 |
| UniProt ID: | Q9HC35 |
| Locus ID: | 27436 |
| COSMIC ID: | EML4 |
| Gene location on chromosome: | 2p21 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 30410 |
| Percent of cancer specimens with mutations: | 0.04 |
| Normal role description: | Encodes for a microtubule binding protein, which may be involved in modification of microtubule dynamics and is essential for correct formation of microtubules. Suggested to play an important role in NSCLC in fusion with ALK (inv(2)(p21p23) with different breakpoints in EML4). |