Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CRLF2 |
| Gene Name: | CRLF2 |
| Protein Full Name: | Cytokine receptor-like factor 2 |
| Alias: | Cytokine receptor-like 2;IL-XR;Thymic stromal lymphopoietin protein receptor |
| Mass (Da): | 42013 |
| Number AA: | 371 |
| UniProt ID: | Q9HC73 |
| Locus ID: | 64109 |
| COSMIC ID: | CRLF2 |
| Gene location on chromosome: | Xp22.3; Yp11.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20407 |
| Percent of cancer specimens with mutations: | 0.26 |
| Commonly recorded point mutations: | F232C (10) |
| Deregulated in translocations: | P2RY8/CRLF2 fusion in 7% of individuals with B-progenitor ALL and in 53% of individuals with ALL associated with Down syndrome. |
| Normal role description: | CRLF2 is a receptor for thymic stromal lymphopoietin (TSLP). Together with the IL-7 receptor and TSLP, CRLF2 activates STAT3/5, and JAK2 pathways, regulating cell proliferation and development of the hematopoietic system. Mutations of the gene are implicated in B-progenitor ALL. |