Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PDE11A |
| Gene Name: | PDE11A |
| Protein Full Name: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 1 |
| Alias: | cAMP and cGMP phosphodiesterase 11A; dual ''''cyclic-AMP and -GMP phosphodiesterase 11A; FLJ23693; MGC133355; MGC133356; PDE11; phosphodiesterase 11A; PPNAD2 |
| Mass (Da): | 104792 |
| Number AA: | 934 |
| Locus ID: | 50940 |
| COSMIC ID: | PDE11A |
| Gene location on chromosome: | 2q31.2 |
| Cancer protein type: | TSP |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 1.27 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with several point mutations, but no complex, insertion or deletion mutants. |
| Mutations observed as inherited: | Adrenocortical tumors and testicular tumor |
| Normal role description: | Catalyzes the hydrolysis of c AMP and c GMP to 5'-AMP and 5'- GMP |