Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GOPC |
| Gene Name: | GOPC |
| Protein Full Name: | Golgi-associated PDZ and coiled-coil motif-contain |
| Alias: | CAL; CFTR-associated ligand; DJ94G16.2; FIG; Fused in glioblastoma; Golgi associated PDZ and coiled-coil motif containing; GOPC; GOPC1; PDZ protein interacting specifically with TC10; PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10 |
| Mass (Da): | 50520 |
| Number AA: | 462 |
| UniProt ID: | Q9HD26 |
| Locus ID: | 57120 |
| COSMIC ID: | GOPC |
| Gene location on chromosome: | 6q22.1 |
| Cancer protein type: | NA |
| Effect of cancer mutation on protein: | NA |
| Effect of active protein on cancer: | NA |
| Number of cancer specimens: | 20075 |
| Percent of cancer specimens with mutations: | 0.3 |
| Normal role description: | NA |
| Commentary on involvement of protein in cancer: | GOPC -> ROS1 translocation in 10% (2/20) CNS (glioblastoma) samples ---> a chimeric protein which has a constitutive receptor tyrosine kinase activity. |