Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PTPRH |
| Gene Name: | PTPRH |
| Protein Full Name: | Receptor-type tyrosine-protein phosphatase H |
| Alias: | protein tyrosine phosphatase, receptor type, H; protein-tyrosine phosphatase receptor H; SAP-1; transmembrane-type protein-tyrosine phosphatase H |
| Mass (Da): | 122820 |
| Number AA: | 1115 |
| UniProt ID: | Q9HD43 |
| Locus ID: | 5794 |
| COSMIC ID: | PTPRH |
| Gene location on chromosome: | 19q13.42 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19731 |
| Percent of cancer specimens with mutations: | 1.14 |
| Normal role description: | PTPRH is a protein-tyrosine phosphatase. It is involved in inhibition of cell growth and cell migration, induces apoptosis, and inhibits TCR stimulation signalling. It is overexpressed in gastric, pancreatic and colon cancers and facilitates tumorigenesis through unknown mechanism. |