Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | IL23A |
| Gene Name: | IL23A |
| Protein Full Name: | Interleukin-23 subunit alpha |
| Alias: | Interleukin-23 subunit p19 |
| Mass (Da): | 20730 |
| Number AA: | 189 |
| UniProt ID: | Q9NPF7 |
| Locus ID: | 51561 |
| COSMIC ID: | IL23A |
| Gene location on chromosome: | 12q13.3 |
| Cancer protein type: | TSP/OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.13 |
| Normal role description: | Gene encodes for a subunit of IL23. The cytokine IL 23 is essential for differentiation of Th17 cells. Activates the JAK/STAT cascade. Promotes production of proinflammatory cytokines and memory effect of T cells. Increased number of SNPs in the IL23R gene in ovarian cancers. Upregulation of IL23A in various cancers. Promotes inflammation and angiogenesis in tumors and inhibits CD8+ T cell infiltration. However growth inhibiting effects have been observed in mouse models. |