Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NLRC4 |
| Gene Name: | NLRC4 |
| Protein Full Name: | NLR family CARD domain-containing protein 4 |
| Alias: | CARD, LRR, and NACHT-containing protein;Caspase recruitment domain-containing protein 12;Ice protease-activating factor |
| Mass (Da): | 116159 |
| Number AA: | 1024 |
| UniProt ID: | Q9NPP4 |
| Locus ID: | 58484 |
| COSMIC ID: | NLRC4 |
| Gene location on chromosome: | 2p22.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19535 |
| Percent of cancer specimens with mutations: | 1.05 |
| Normal role description: | NLRC4 is involved in forming an inflammasome complex in response to flagellin. Formation of the complex induces cleavage of caspase-1 to cleave and activate IL-1B. It is also involved in apoptosis induced by p53. Loss of NLRC4 promotes oncogenesis during inflammation by reduced apoptosis rates and increased proliferation of epithelial cell in colitus induced colorectal cancer mice models. |