Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TRIM36 |
| Gene Name: | TRIM36 |
| Protein Full Name: | E3 ubiquitin-protein ligase TRIM36 |
| Alias: | RING finger protein 98;Tripartite motif-containing protein 36;Zinc-binding protein Rbcc728 |
| Mass (Da): | 83012 |
| Number AA: | 728 |
| UniProt ID: | Q9NQ86 |
| Locus ID: | 55521 |
| COSMIC ID: | TRIM36 |
| Gene location on chromosome: | 5q22.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20215 |
| Percent of cancer specimens with mutations: | 0.63 |
| Normal role description: | TRIM36 is a protein belonging to the tripartite motif family of proteins. The exact function of TRIM36 has not been well studied but is suggested to possess E3 ubiquitin ligase activity. TRIM36 was found to interact with centromere protein-H (CENP-H) and to decelerate cell cycle progression when overexpressed. It has been speculated that overexpression of TRIM36 may lead to chromosomal instability and cancer development. TRIM36 has been found to be overexpressed in prostate cancer. |
| Commentary on involvement of protein in cancer: | OG in prostate cancer. Less than 3% mutation in breast and lung cancer. |