Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ANLN |
| Gene Name: | ANLN |
| Protein Full Name: | Actin-binding protein anillin |
| Alias: | Actin binding protein anillin; ANILLIN; Anillin, actin binding protein; Anln; Scra; Scraps; Scraps homolog, Drosophila; Similar to anillin, actin binding protein |
| Mass (Da): | 124199 |
| Number AA: | 1124 |
| UniProt ID: | Q9NQW6 |
| Locus ID: | 54443 |
| COSMIC ID: | ANLN |
| Gene location on chromosome: | 7p14.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 1.01 |
| Normal role description: | ANLN is an actin binding protein that localizes to the cellular membrane and nucleus. It plays a critical role in the formation of the cleavage furrow during cytokinesis by assembling the actin and myosin contractile ring. It has also been involved in the breakdown of the nuclear envelope and cell cycle progression. In cancer, overexpression of ANLN is implicated in stimulating growth pathways via RHOA and cell division. |