Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PRDM5 |
| Gene Name: | PRDM5 |
| Protein Full Name: | PR domain zinc finger protein 5 |
| Alias: | PFM2; PR domain containing 5; PR domain-containing 5 |
| Mass (Da): | 73062 |
| Number AA: | 630 |
| UniProt ID: | Q9NQX1 |
| Locus ID: | 11107 |
| COSMIC ID: | PRDM5 |
| Gene location on chromosome: | 4q27 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.73 |
| Gene undergoes hypermethylation: | Yes in cervical cancer |
| Normal role description: | Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M arrest and apoptosis in cancer cells (UniPROT quote) |