Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SMYD2 |
| Gene Name: | SMYD2 |
| Protein Full Name: | SET and MYND domain-containing protein 2 |
| Alias: | HSKM-B; SET and MYND domain containing 2 |
| Mass (Da): | 49688 |
| Number AA: | 433 |
| UniProt ID: | Q9NRG4 |
| Locus ID: | 56950 |
| COSMIC ID: | SMYD2 |
| Gene location on chromosome: | 1q32.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.33 |
| Found in amplified chromosomal regions in human cancers: | Esophageal squamous cell carcinoma (25.6%) |
| Normal role description: | Acts as methyltransferase for histone 3 and p53 (represses tumour suppressor activity of p53). May promote cell proliferation and/or differentiation. Methylates the retinoblastoma tumour suppressor (RB). Overexpression and low expression levels associated with human cancers. |
| Commentary on involvement of protein in cancer: | No mutations reported on the Atlas of Oncology. |