Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ADARB2 |
| Gene Name: | ADARB2 |
| Protein Full Name: | Double-stranded RNA-specific editase B2 |
| Alias: | dsRNA adenosine deaminase B2 |
| Mass (Da): | 80603 |
| Number AA: | 739 |
| UniProt ID: | Q9NS39 |
| Locus ID: | 105 |
| COSMIC ID: | ADARB2 |
| Gene location on chromosome: | 10p15.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19902 |
| Percent of cancer specimens with mutations: | 0.99 |
| Normal role description: | A member of RNA adenosine deaminase RNA editing family of enzymes. It is capable of binding to both double stranded and single stranded and inhibited RNA editing of other ADAR genes in vitro. It functions in altering the RNA sequence to produce a different RNA gene product and possibly protein product than predicted from DNA gene sequence. Alterations in RNA plays many regulatory roles such as degradation, stabilization, retention, splicing, translation and more. Dysregulated alterations often lead to many diseases and as well as cancer. |