Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TOPORS |
| Gene Name: | TOPORS |
| Protein Full Name: | E3 ubiquitin-protein ligase Topors |
| Alias: | LUN; LUN-1; RP31; SUMO1-protein E3 ligase Topors; Topoisomerase I binding arginine/serine-rich; Topoisomerase I binding, arginine/serine-rich; TOPRS; TP53BPL; Tumor protein p53-binding protein |
| Mass (Da): | 119198 |
| Number AA: | 1045 |
| UniProt ID: | Q9NS56 |
| Locus ID: | 10210 |
| COSMIC ID: | TOPORS |
| Gene location on chromosome: | 9p21.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.05 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | TOPORS is a E3 ubiquitin-protein ligase that has decreases cell proliferation and apoptosis by increasing p53/TP53 stability through ubiquitin-dependent degradation of its inhibitors. It may also induce apoptosis following DNA damage through IKBKE sumoylation. Expression is commonly decreased in colon and lung cancers, and loss of heterozygosity is also associated with different malignancies. |