Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ST6GALNAC1 |
| Gene Name: | ST6GALNAC1 |
| Protein Full Name: | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltran |
| Alias: | GalNAc alpha-2,6-sialyltransferase I; HSY11339; SIA7A; Sialyltransferase 7A; SIAT7A; ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc I; ST6GalNAcI |
| Mass (Da): | 68564 |
| Number AA: | 600 |
| UniProt ID: | Q9NSC7 |
| Locus ID: | 55808 |
| COSMIC ID: | ST6GALNAC1 |
| Gene location on chromosome: | 17q25.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.47 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | ST6GALNAc1 is a sialyltransferase that glycosylates proteins involved in cell-cell and cell-matrix interactions, and intracellular signalling. The cancer-associated antigen sialyl-Tn is formed by ST6GALNAC1-catalyzed glycosylation on mucins. This cancer antigen on transformed epithelial cells has been shown to induce morphologic changes and migration. Overexpression is correlated with decreased survival. |