Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SAMSN1 |
| Gene Name: | SAMSN1 |
| Protein Full Name: | SAM domain-containing protein SAMSN-1 |
| Alias: | NASH1; nuclear localization signals, SAM and SH3 domain containing 1; SAM and SH3 domain containing 2; SAM domain, SH3 domain and nuclear localisation signals protein 1; SAM domain, SH3 domain and nuclear localization signals 1; SAM-domain protein SAMSN-1; SAMN1; SASH2; SH3D6B; SSN1 |
| Mass (Da): | 41708 |
| Number AA: | 373 |
| UniProt ID: | Q9NSI8 |
| Locus ID: | 6409 |
| COSMIC ID: | SAMSN1 |
| Gene location on chromosome: | 21q11 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.61 |
| Normal role description: | SAMSN1 is part of a novel gene family of putative adaptors/scaffold proteins that contain both SH3 and SAM (sterile alpha motif) domains. SAMSN1 has been shown to negatively regulate B-cell activation. It also downregulates cell proliferation and stimulated HDAC1 activity. Missense mutations in this gene have been observed in ovarian and pancreatic tumors. |
| Commentary on involvement of protein in cancer: | Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation |