Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PDS5B |
| Gene Name: | PDS5B |
| Protein Full Name: | Sister chromatid cohesion protein PDS5 homolog B |
| Alias: | Androgen-induced proliferation inhibitor; Androgen-induced shutoff 3; AS3; CG008; FLJ23236; KIAA0979; Sister chromatid cohesion protein PDS5 homolog B: Androgen-induced proliferation inhibitor: Androgen-induced prostate proliferative shutoff-associated protein AS3: Sister chromatid cohesion protein PDS5 homolog B: Androgen-induced proliferation inhibitor: Androgen-induced prostate proliferative shutoff-associated protein AS3 |
| Mass (Da): | 164667 |
| Number AA: | 1447 |
| UniProt ID: | Q9NTI5 |
| Locus ID: | 23047 |
| COSMIC ID: | PDS5B |
| Gene location on chromosome: | 13q13.1 |
| Cancer protein type: | TSP? |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19713 |
| Percent of cancer specimens with mutations: | 1.13 |
| Normal role description: | PDS5B binds and stabilizes the cohesion complex which is responsible for interating with sister chromatids and accurate chromosome segregation during mitosis and meiosis. It also plays a role in DNA repair and negative regulation of cell proliferation. |