Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FAIM |
| Gene Name: | FAIM |
| Protein Full Name: | Fas apoptotic inhibitory molecule 1 |
| Alias: | FAIM1; Fas apoptotic inhibitory molecule; FLJ10582 |
| Mass (Da): | 20215 |
| Number AA: | 179 |
| UniProt ID: | Q9NVQ4 |
| Locus ID: | 55179 |
| COSMIC ID: | FAIM |
| Gene location on chromosome: | 3q22.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.12 |
| Normal role description: | FAIM is a Fas kinase antagonist and is involved in inhibiting Fas-mediated apoptosis. Two isoforms of FAIM exist, FAIM-S and FAIM-L with FAIM-S being more widely expressed than FAIM-L. FAIM-L is predominantly expressed in neuronal tissue and appears to have a role in prolonging cell longevity in these tissues. There are no known mutations associated with cancer development. Overexpression of FAIM-L causes cells to resist apoptosis induced by death receptors such as Fas or TNFR1. Thus FAIM may have a role in cancer progression through preventing apoptosis. |