Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DDX43 |
| Gene Name: | DDX43 |
| Protein Full Name: | Probable ATP-dependent RNA helicase DDX43 |
| Alias: | Cancer/testis antigen 13; CT13; DEAD (Asp-Glu-Ala-Asp) box polypeptide 43; DEAD box protein 43; DEAD box protein HAGE; DKFZp434H2114; EC 3.6.1.-; HAGE; Helical antigen |
| Mass (Da): | 72844 |
| Number AA: | 648 |
| UniProt ID: | Q9NXZ2 |
| Locus ID: | 55510 |
| COSMIC ID: | DDX43 |
| Gene location on chromosome: | 6q13 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.7 |
| Normal role description: | 55% similarity with the human p68 protein, an ATP-dependent RNA helicase. Expressed in many tumors of various histological types at a level that is 100-fold higher than the level observed in normal tissues. This may be compensatory or driving oncogenesis. |