Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ABI2 |
| Gene Name: | ABI2 |
| Protein Full Name: | Abl interactor 2 |
| Alias: | Abelson interactor 2; ABI-2; ABI2B; Abl binding protein 3; Abl-binding protein 3; AblBP3; Abl-interactor 2; AIP-1; Arg binding protein 1; Arg-binding protein 1; ArgBP1; ARGBPIA; SSH3BP2 |
| Mass (Da): | 55663 |
| Number AA: | 513 |
| UniProt ID: | Q9NYB9 |
| Locus ID: | 10152 |
| COSMIC ID: | ABI2 |
| Gene location on chromosome: | 2q33 |
| Cancer protein type: | UNCLEAR (likely TSP) |
| Effect of cancer mutation on protein: | UNCLEAR (likely loss of function) |
| Effect of active protein on cancer: | UNCLEAR (likely inhibits) |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.3 |
| Normal role description: | ABI2 is a substrate of ABL1 and ABL2 tyrosine kinase; through this interaction, ABI2 may play a role in cell growth and tranformation. ABI2 also regulates lamellipodia formatios, as it is part of the WAVE complex. No mutations in this gene are currently associated with cancer. |
| Commentary on involvement of protein in cancer: | May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.Immunoblot and autoradiographic analyses indicated that ABI2 is phosphorylated by ABL1. Dai and Pendergast (1995) suggested that the ABI proteins may function to coordinate the cytoplasmic and nuclear functions of the ABL1 tyrosine kinase. No transforming mutations were identified in the Atlas of Gene Oncology, the Sanger COSMIC database, or Uniprot for this gene. |