Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FAT2 |
| Gene Name: | FAT2 |
| Protein Full Name: | Protocadherin Fat 2 |
| Alias: | CDHF8; FAT tumor suppressor 2; HFat2; HFAT2; MEGF1; Multiple epidermal growth factor-like domains 1; Protocadherin Fat 2 cadherin family member 8 |
| Mass (Da): | 479392 |
| Number AA: | 4349 |
| UniProt ID: | Q9NYQ8 |
| Locus ID: | 2196 |
| COSMIC ID: | FAT2 |
| Gene location on chromosome: | 5q33.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19750 |
| Percent of cancer specimens with mutations: | 3.5 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with point mutations but no insertions or deletions. |
| Normal role description: | FAT2 is an integral membrane protein involved in regulating cell proliferation, migration of epidermal cells, cerebellum development and modulating the extracellular space surrounding parallel fibres of cerebellar. It is often inactivated during carcinogenesis. |