Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FAM120A |
| Gene Name: | FAM120A |
| Protein Full Name: | Constitutive coactivator of PPAR-gamma-like protei |
| Alias: | C9orf10; CI010; F120A; Family with sequence similarity 120A; KIAA0183; Oxidative stress-associated Src activator; Protein FAM120A |
| Mass (Da): | 121888 |
| Number AA: | 1118 |
| UniProt ID: | Q9NZB2 |
| Locus ID: | 23196 |
| COSMIC ID: | FAM120A |
| Gene location on chromosome: | 9q22.31 |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.68 |
| Commentary on involvement of protein in cancer: | May participate in mRNA transport in the cytoplasm By similarity. Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses. |