Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | IGF2BP1 |
| Gene Name: | IGF2BP1 |
| Protein Full Name: | Insulin-like growth factor 2 mRNA-binding protein |
| Alias: | Coding region determinant-binding protein; CRDBP; CRD-BP; IF2B1; IGF II mRNA binding protein 1; IGF-II mRNA-binding protein 1; IMP1; Insulin-like growth factor 2 mRNA binding protein 1; MRNA-binding protein CRDBP; Oncofetal protein ZBP1; VICKZ family member 1; VICKZ1; ZBP1; Zip code-binding protein 1 |
| Mass (Da): | 63456 |
| Number AA: | 577 |
| UniProt ID: | Q9NZI8 |
| Locus ID: | 10642 |
| COSMIC ID: | IGF2BP1 |
| Gene location on chromosome: | 17q21.32 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19805 |
| Percent of cancer specimens with mutations: | 0.72 |
| Normal role description: | IGF2BP1 is a member of the insulin-like growth factor 2 mRNA-binding protein family. Its role is to regulate translation by binding mRNAs of certain genes, including IGF2 -- a pro-oncogene. |