Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GLTSCR2 |
| Gene Name: | GLTSCR2 |
| Protein Full Name: | Glioma tumor suppressor candidate region gene 2 pr |
| Alias: | GSCR2; p60 |
| Mass (Da): | 54389 |
| Number AA: | 478 |
| UniProt ID: | Q9NZM5; Q7L4X7; B4DVK1 |
| Locus ID: | 29997 |
| COSMIC ID: | GLTSCR2 |
| Gene location on chromosome: | 19q13.32; 19q13.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.34 |
| Normal role description: | GLTSCR2 is a nuclear localized protein found to physically interact with and regulate the tumour suppressor protein PTEN. GLTSCR2 was found to increase PTEN stability in cells and may have a role in inducing apoptosis in cells. The GLTSCR2 locus is frequently underexpressed in glioma and neuroblastomas and aberrant expression of GLTSCR2 has been linked with the development of these cancers. |