Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NckIPSD |
| Gene Name: | NCKIPSD |
| Protein Full Name: | NCK-interacting protein with SH3 domain |
| Alias: | AF3p21; Dia interacting protein; Dia interacting protein-1; Dia-interacting protein 1; Diaphanous protein interacting protein; Diaphanous protein-interacting protein; DIP1; DIP-1; NCK interacting protein with SH3 domain; ORF1; SH3 adapter protein SPIN90; SH3 protein interacting with Nck, 90 kDa; SPIN90; SPN90; VacA-interacting protein, 54 kDa; VIP54; WASLBP; WISH |
| Mass (Da): | 78960 |
| Number AA: | 722 |
| UniProt ID: | Q9NZQ3 |
| Locus ID: | 51517 |
| COSMIC ID: | NCKIPSD |
| Gene location on chromosome: | 3p21 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20150 |
| Percent of cancer specimens with mutations: | 0.37 |
| Deregulated in translocations: | MLL |
| Normal role description: | A nuclear protein that is invovled with stress fibre formation, sacromere maintanence and formation of microfibrils in sacromeres. It induces microspike in vivo and has also been implicated in actin polymerization and cell adhesion. It has been found to be implicated in treatment related acute non lymphoblastic leukemia by a translocation event to the myeloid/lymphoid leukemia gene. |
| Commentary on involvement of protein in cancer: | Sanger had no report of this gene |