Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LRP1B |
| Gene Name: | LRP1B |
| Protein Full Name: | Low-density lipoprotein receptor-related protein 1 |
| Alias: | Low-density lipoprotein receptor-related protein-deleted in tumor; LRPDIT; LRP-DIT |
| Mass (Da): | 515498 |
| Number AA: | 4599 |
| UniProt ID: | Q9NZR2; Q8WY26; Q8WY27; Q8WY28 |
| Locus ID: | 53353 |
| COSMIC ID: | LRP1B |
| Gene location on chromosome: | 2q21.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20143 |
| Percent of cancer specimens with mutations: | 7.3 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with point mutations but no insertions or deletions. |
| Normal role description: | Potential cell surface protein, that belongs to the family of LDL (low density lipoprotein) receptors. May bind and internalize ligands in the process of receptor-mediated endocytosis. |