Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | KCMF1 |
| Gene Name: | KCMF1 |
| Protein Full Name: | E3 ubiquitin-protein ligase KCMF1 |
| Alias: | Potassium channel modulatory factor |
| Mass (Da): | 41927 |
| Number AA: | 381 |
| UniProt ID: | Q9P0J7 |
| Locus ID: | 56888 |
| COSMIC ID: | KCMF1 |
| Gene location on chromosome: | 2p11.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19535 |
| Percent of cancer specimens with mutations: | 0.33 |
| Normal role description: | KCMF1 plays a role a transcription factor and as ubiquitin ligase, as well a possibly ion channel activity. It upregulates certain genes during growth factor induction. Upregulation of this gene is present in gastric cancer. |
| Commentary on involvement of protein in cancer: | Up-regulated by FGF2 in gastric cancer cells. |