Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Pim2 |
| Gene Name: | PIM2 |
| Protein Full Name: | Serine/threonine-protein kinase pim-2 |
| Alias: | EC 2.7.11.1; Pim-2h |
| Mass (Da): | 34190 |
| Number AA: | 311 |
| UniProt ID: | Q9P1W9 |
| Locus ID: | 11040 |
| COSMIC ID: | PIM2 |
| Gene location on chromosome: | 1q32.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19535 |
| Percent of cancer specimens with mutations: | 0.28 |
| Deregulated by viral insertion: | Moloney murine leukemia virus (MoMLV) - Mouse |
| Normal role description: | PIM2 is a protein-serine/threonine kinase implicated in cell survival and proliferation signalling. It regulations MYC transcription and stabilization by phosphorylation. It also prevents apoptosis by phosphorylating and inactivating BAD, a proapoptotic protein. It induces cell survival and proliferation signals via NF-KB cascade and phosphorylation of CDKN1A and CDKN1B. Dysregulation of PIM2 can promote cell proliferation and resistance to apoptosis and oncogenesis |